› 8hnk

Electron Microscopy
3.01Å resolution

CXCR3-DNGi complex activated by CXCL11

Released:
DOI: 10.2210/pdb8hnk/pdb
PDB entry 8hnk coloured by chain, front view.
PDB entry 8hnk coloured by chain, side view.
PDB entry 8hnk coloured by chain, top view.
Source organisms:
Primary publication:
Structural insights into the activation and inhibition of CXC chemokine receptor 3.
Jiao H, Pang B, Liu A, Chen Q, Pan Q, Wang X, Xu Y, Chiang YC, Ren R, Hu H
OpenAccess logo Nat Struct Mol Biol (2024)
PMID: 38177682
Related structures: EMD-34914

Function and Biology Details

Reaction catalysed: 
Oplophorus luciferin + O(2) = oxidized Oplophorus luciferin + CO(2) + light
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-279321 (preferred)
Entry contents:
6 distinct polypeptide molecules
Macromolecules (6 distinct):
Guanine nucleotide-binding protein G(i) subunit alpha-1 Chain: A
Molecule details ›
Chain: A
Length: 354 amino acids
Theoretical weight: 40.45 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Chain: B
Molecule details ›
Chain: B
Length: 384 amino acids
Theoretical weight: 42.01 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Chain: G
Molecule details ›
Chain: G
Length: 71 amino acids
Theoretical weight: 7.86 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
C-X-C chemokine receptor type 3; Oplophorus-luciferin 2-monooxygenase catalytic subunit; Soluble cytochrome b562 Chain: R
Molecule details ›
Chain: R
Length: 657 amino acids
Theoretical weight: 72.92 KDa
Source organism: Escherichia coli
Expression system: Spodoptera frugiperda
C-X-C motif chemokine 11 Chain: L
Molecule details ›
Chain: L
Length: 104 amino acids
Theoretical weight: 11.76 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
single-chain variable fragment scFv16 Chain: S
Molecule details ›
Chain: S
Length: 259 amino acids
Theoretical weight: 27.78 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda

Ligands and Environments

1 bound ligand:
Ligand CLR 2 x CLR
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.01Å
Relevant EMDB volumes: EMD-34914
Expression system: Spodoptera frugiperda

Quick links

Citations

2 review citations

G protein-coupled receptors (GPCRs): advances in structures, mechanisms, and drug discovery.
Zhang et al. (2024)
1 more

1 mention without citation

Structural insights into the activation and inhibition of CXC chemokine receptor 3.
Jiao et al. (2024)