› 8hoh

X-ray diffraction
1.9Å resolution

Crystal structure of Bcl-2 G101V in complex with sonrotoclax

Released:
DOI: 10.2210/pdb8hoh/pdb
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PDB entry 8hoh coloured by chain, front view.
PDB entry 8hoh coloured by chain, side view.
PDB entry 8hoh coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Sonrotoclax overcomes BCL2 G101V mutation-induced venetoclax resistance in preclinical models of hematologic malignancy.
Liu J, Li S, Wang Q, Feng Y, Xing H, Yang X, Guo Y, Guo Y, Sun H, Liu X, Yang S, Mei Z, Zhu Y, Cheng Z, Chen S, Xu M, Zhang W, Wan N, Wang J, Ma Y, Zhang S, Luan X, Xu A, Li L, Wang H, Yang X, Hong Y, Xue H, Yuan X, Hu N, Song X, Wang Z, Liu X, Wang L, Liu Y
Blood (2024)
PMID: 38211332

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145305 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Apoptosis regulator Bcl-2 Chain: A
Molecule details ›
Chain: A
Length: 162 amino acids
Theoretical weight: 19.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P10415 (Residues: 5-207; Coverage: 68%)
Gene name: BCL2
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand 98I 1 x 98I
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: P212121
Unit cell:
a: 32.479Å b: 48.036Å c: 106.418Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.229 0.227 0.257
Expression system: Escherichia coli

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