› 8hps

Electron Microscopy
3.51Å resolution

LpqY-SugABC in state 5

Released:
DOI: 10.2210/pdb8hps/pdb
PDB entry 8hps coloured by chain, front view.
PDB entry 8hps coloured by chain, side view.
PDB entry 8hps coloured by chain, top view.
Source organism: Mycolicibacterium smegmatis MC2 155
Primary publication:
Structural insights into trehalose capture and translocation by mycobacterial LpqY-SugABC.
Liang J, Yang X, Hu T, Gao Y, Yang Q, Yang H, Peng W, Zhou X, Guddat LW, Zhang B, Rao Z, Liu F
Structure (2023)
PMID: 37619560
Related structures: EMD-34942

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
PDBe Complex ID:
PDB-CPX-106430 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (5 distinct):
ABC transmembrane type-1 domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 305 amino acids
Theoretical weight: 32.74 KDa
Source organism: Mycolicibacterium smegmatis MC2 155
Expression system: Mycolicibacterium smegmatis MC2 155
UniProt:
  • Canonical: A0R2C2 (Residues: 1-305; Coverage: 100%)
Gene name: MSMEG_5060
Sequence domains: Binding-protein-dependent transport system inner membrane component
ABC transmembrane type-1 domain-containing protein Chain: B
Molecule details ›
Chain: B
Length: 278 amino acids
Theoretical weight: 29.84 KDa
Source organism: Mycolicibacterium smegmatis MC2 155
Expression system: Mycolicibacterium smegmatis MC2 155
UniProt:
  • Canonical: A0R2C1 (Residues: 1-278; Coverage: 100%)
Gene name: MSMEG_5059
Sequence domains: Binding-protein-dependent transport system inner membrane component
ABC transporter domain-containing protein Chains: C, D
Molecule details ›
Chains: C, D
Length: 406 amino acids
Theoretical weight: 43.7 KDa
Source organism: Mycolicibacterium smegmatis MC2 155
Expression system: Mycolicibacterium smegmatis MC2 155
UniProt:
  • Canonical: A0R2C0 (Residues: 1-406; Coverage: 100%)
Gene name: MSMEG_5058
Sequence domains:
Bacterial extracellular solute-binding protein Chain: E
Molecule details ›
Chain: E
Length: 465 amino acids
Theoretical weight: 50.18 KDa
Source organism: Mycolicibacterium smegmatis MC2 155
Expression system: Mycolicibacterium smegmatis MC2 155
UniProt:
  • Canonical: A0R2C3 (Residues: 1-465; Coverage: 100%)
Gene name: MSMEG_5061
Sequence domains: Bacterial extracellular solute-binding protein

Ligands and Environments

Carbohydrate polymer : NEW Components: GLC
Carbohydrate polymer
2 bound ligands:
Ligand ATP 2 x ATP
Ligand MG 2 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.51Å
Relevant EMDB volumes: EMD-34942
Expression system: Mycolicibacterium smegmatis MC2 155

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