› 8hti

Electron Microscopy
2.97Å resolution

Human Consensus Olfactory Receptor OR52c in Complex with Octanoic Acid (OCA) and G Protein

Released:
DOI: 10.2210/pdb8hti/pdb
PDB entry 8hti coloured by chain, front view.
PDB entry 8hti coloured by chain, side view.
PDB entry 8hti coloured by chain, top view.
Source organisms:
Primary publication:
Understanding the molecular mechanisms of odorant binding and activation of the human OR52 family.
Choi C, Bae J, Kim S, Lee S, Kang H, Kim J, Bang I, Kim K, Huh WK, Seok C, Park H, Im W, Choi HJ
OpenAccess logo Nat Commun 14 8105 (2023)
PMID: 38062020
Related structures: EMD-35010

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
PDBe Complex ID:
PDB-CPX-548144 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Chain: A
Molecule details ›
Chain: A
Length: 393 amino acids
Theoretical weight: 45.89 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P63092 (Residues: 2-394; Coverage: 96%)
  • Best match: P63092-2 (Residues: 2-380)
Gene names: GNAS, GNAS1, GSP
Sequence domains: G-protein alpha subunit
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Chain: B
Molecule details ›
Chain: B
Length: 357 amino acids
Theoretical weight: 39.29 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P62873 (Residues: 2-340; Coverage: 100%)
Gene name: GNB1
Sequence domains: WD domain, G-beta repeat
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Chain: G
Molecule details ›
Chain: G
Length: 71 amino acids
Theoretical weight: 7.86 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P59768 (Residues: 1-71; Coverage: 100%)
Gene name: GNG2
Sequence domains: GGL domain
Nanobody 35 Chain: N
Molecule details ›
Chain: N
Length: 138 amino acids
Theoretical weight: 15.14 KDa
Source organism: Lama glama
Expression system: Escherichia coli
Consensus Olfactory Receptor OR52c Chain: R
Molecule details ›
Chain: R
Length: 323 amino acids
Theoretical weight: 36.5 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda

Ligands and Environments

1 bound ligand:
Ligand OCA 1 x OCA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.97Å
Relevant EMDB volumes: EMD-35010
Expression systems:
  • Spodoptera frugiperda
  • Escherichia coli

Quick links

Citations

2 citation in other articles

A pattern recognition artificial olfactory system based on human olfactory receptors and organic synaptic devices.
Song et al. (2024)
1 more