› 8hu7

X-ray diffraction
1.4Å resolution

Crystal structure of FGF2-M1 mutant - D28E/C78L/C96I/S137P

Released:
DOI: 10.2210/pdb8hu7/pdb
PDB entry 8hu7 coloured by chain, front view.
PDB entry 8hu7 coloured by chain, side view.
PDB entry 8hu7 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and biochemical investigation into stable FGF2 mutants with novel mutation sites and hydrophobic replacements for surface-exposed cysteines.
An YJ, Jung YE, Lee KW, Kaushal P, Ko IY, Shin SM, Ji S, Yu W, Lee C, Lee WK, Cha K, Lee JH, Cha SS, Yim HS
PLoS One 19 e0307499 (2024)
PMID: 39236042

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140533 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fibroblast growth factor 2 Chain: A
Molecule details ›
Chain: A
Length: 147 amino acids
Theoretical weight: 16.61 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P09038 (Residues: 142-288; Coverage: 51%)
Gene names: FGF2, FGFB
Sequence domains: Fibroblast growth factor

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 11C
Spacegroup: P3121
Unit cell:
a: 54.375Å b: 54.375Å c: 97.012Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.185 0.185 0.213
Expression system: Escherichia coli

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