8hvh

Electron Microscopy
3.07Å resolution

Cryo-EM structure of ABC transporter ABCC3

Released:

Function and Biology Details

Reactions catalysed:
ATP + H(2)O + xenobiotic(Side 1) = ADP + phosphate + xenobiotic(Side 2)
ATP + H(2)O + glutathione-S-conjugate(Side 1) = ADP + phosphate + glutathione-S-conjugate(Side 2)
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
PDBe Complex ID:
PDB-CPX-217250 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ATP-binding cassette sub-family C member 3 Chain: A
Molecule details ›
Chain: A
Length: 1527 amino acids
Theoretical weight: 169.5 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O15438 (Residues: 1-1527; Coverage: 100%)
Gene names: ABCC3, CMOAT2, MLP2, MRP3
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.07Å
Relevant EMDB volumes: EMD-35043
Expression system: Homo sapiens