8hxb

Electron Microscopy
2.7Å resolution

Cryo-EM structure of MPXV M2 hexamer in complex with human B7.2

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
hetero dodecamer (preferred)
PDBe Complex ID:
PDB-CPX-269541 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Early protein OPG038 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 203 amino acids
Theoretical weight: 23.29 KDa
Source organism: Monkeypox virus
Expression system: Homo sapiens
UniProt:
  • Canonical: A0A7H0DN11 (Residues: 18-220; Coverage: 100%)
Gene names: M2L, MPXVgp026, OPG038
Sequence domains: Poxvirus M2 protein
T-lymphocyte activation antigen CD86 Chains: G, H, I, J, K, L
Molecule details ›
Chains: G, H, I, J, K, L
Length: 213 amino acids
Theoretical weight: 24.42 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P42081 (Residues: 26-238; Coverage: 70%)
Gene names: CD28LG2, CD86
Sequence domains: Immunoglobulin V-set domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.7Å
Relevant EMDB volumes: EMD-35075
Expression system: Homo sapiens