Function and Biology

Crystal structure of B1 VIM-2 MBL in complex with 2-amino-5-isobutylthiazole-4-carboxylic acid

Source organism: Pseudomonas aeruginosa
Biochemical function: metal ion binding
Biological process: antibiotic catabolic process
Cellular component: not assigned

EC 3.5.2.6: Beta-lactamase

Reaction catalysed:
A beta-lactam + H(2)O = a substituted beta-amino acid
Systematic name:
Beta-lactam hydrolase
Alternative Name(s):
  • Ampicillinase
  • Beta-lactamase A, B, C
  • Beta-lactamase AME I
  • Beta-lactamase I-III
  • Cephalosporin-beta-lactamase
  • Cephalosporinase
  • Exopenicillinase
  • Neutrapen
  • Penicillin amido-beta-lactamhydrolase
  • Penicillin beta-lactamase
  • Penicillinase
  • Penicillinase I, II

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00753
Domain description: Metallo-beta-lactamase superfamily
Occurring in:
  1. Metallo-beta-lactamase type 2
The deposited structure of PDB entry 8hxo contains 2 copies of Pfam domain PF00753 (Metallo-beta-lactamase superfamily) in Metallo-beta-lactamase domain-containing protein. Showing 1 copy in chain A.