› 8hyn

X-ray diffraction
2.09Å resolution

Bacterial STING from Riemerella anatipestifer

Released:
DOI: 10.2210/pdb8hyn/pdb
PDB entry 8hyn coloured by chain, front view.
PDB entry 8hyn coloured by chain, side view.
PDB entry 8hyn coloured by chain, top view.
Source organism: Riemerella anatipestifer Yb2
Primary publication:
Structural insights into the regulation, ligand recognition, and oligomerization of bacterial STING.
Hou MH, Wang YC, Yang CS, Liao KF, Chang JW, Shih O, Yeh YQ, Sriramoju MK, Weng TW, Jeng US, Hsu SD, Chen Y
OpenAccess logo Nat Commun 14 8519 (2023)
PMID: 38129386

Function and Biology Details

Reaction catalysed: 
NAD(+) + H(2)O = ADP-D-ribose + nicotinamide
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-243398 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CD-NTase-associated protein 12 Chains: A, B
Molecule details ›
Chains: A, B
Length: 163 amino acids
Theoretical weight: 18.56 KDa
Source organism: Riemerella anatipestifer Yb2
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: E4TDY5 (Residues: 158-316; Coverage: 50%)
Gene name: RA0C_0042
Sequence domains: Prokaryotic STING domain

Ligands and Environments

1 bound ligand:
Ligand PG4 2 x PG4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE BL13B1
Spacegroup: P212121
Unit cell:
a: 53.265Å b: 60.121Å c: 118.823Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.192 0.189 0.239
Expression system: Escherichia coli BL21

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