8i0q

Electron Microscopy
4.45Å resolution

Structure of beta-arrestin1 in complex with a phosphopeptide corresponding to the human C-X-C chemokine receptor type 4, CXCR4 (Local refine)

Released:

Function and Biology Details

Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
PDBe Complex ID:
PDB-CPX-273492 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Beta-arrestin-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 418 amino acids
Theoretical weight: 47.09 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P29066 (Residues: 1-418; Coverage: 100%)
Gene name: Arrb1
Sequence domains:
Fab30 Heavy Chain Chains: H, I
Molecule details ›
Chains: H, I
Length: 237 amino acids
Theoretical weight: 25.51 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
Fab30 Light Chain Chains: L, M
Molecule details ›
Chains: L, M
Length: 215 amino acids
Theoretical weight: 23.44 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
C-X-C chemokine receptor type 4 Chains: U, V
Molecule details ›
Chains: U, V
Length: 17 amino acids
Theoretical weight: 2.38 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P61073 (Residues: 336-352; Coverage: 5%)
Gene name: CXCR4

Ligands and Environments

No bound ligands
2 modified residues:

Experiments and Validation Details

Entry percentile scores
Resolution: 4.45Å
Relevant EMDB volumes: EMD-35106
Expression systems:
  • Escherichia coli
  • Not provided