› 8i3v

Electron Microscopy
2.85Å resolution

Cryo-EM structure of human norepinephrine transporter NET in the presence of the antidepressant escitalopram in an inward-open state at resolution of 2.85 angstrom.

Released:
DOI: 10.2210/pdb8i3v/pdb
PDB entry 8i3v coloured by chain, front view.
PDB entry 8i3v coloured by chain, side view.
PDB entry 8i3v coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular basis of human noradrenaline transporter reuptake and inhibition.
Tan J, Xiao Y, Kong F, Zhang X, Xu H, Zhu A, Liu Y, Lei J, Tian B, Yuan Y, Yan C
Nature (2024)
PMID: 39048818
Related structures: EMD-35157

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-273409 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sodium-dependent noradrenaline transporter Chain: A
Molecule details ›
Chain: A
Length: 617 amino acids
Theoretical weight: 69.39 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P23975 (Residues: 1-617; Coverage: 100%)
Gene names: NAT1, NET1, SLC6A2, SLC6A5
Sequence domains: Sodium:neurotransmitter symporter family

Ligands and Environments

2 bound ligands:
Ligand 68P 1 x 68P
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.85Å
Relevant EMDB volumes: EMD-35157
Expression system: Homo sapiens

Quick links

Citations

1 citations in other articles

Fluorescent non-canonical amino acid provides insight into the human serotonin transporter.
Nygaard et al. (2024)