8i5y

Electron Microscopy
2.6Å resolution

Structure of human Nav1.7 in complex with vixotrigine

Released:
Source organism: Homo sapiens
Primary publication:
Structural mapping of Nav1.7 antagonists.
OpenAccess logo Nat Commun 14 3224 (2023)
PMID: 37270609
Related structures: EMD-35198

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-130219 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
Sodium channel protein type 9 subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 2028 amino acids
Theoretical weight: 230.92 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q15858 (Residues: 1-1988; Coverage: 100%)
Gene names: NENA, SCN9A
Sequence domains:
Sodium channel regulatory subunit beta-1 Chain: B
Molecule details ›
Chain: B
Length: 218 amino acids
Theoretical weight: 24.73 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q07699 (Residues: 1-218; Coverage: 100%)
Gene name: SCN1B
Sequence domains: Immunoglobulin V-set domain
Sodium channel regulatory subunit beta-2 Chain: C
Molecule details ›
Chain: C
Length: 215 amino acids
Theoretical weight: 24.36 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O60939 (Residues: 1-215; Coverage: 100%)
Gene names: SCN2B, UNQ326/PRO386
Sequence domains: Immunoglobulin V-set domain

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.6Å
Relevant EMDB volumes: EMD-35198
Expression system: Homo sapiens