› 8idd

Electron Microscopy
4Å resolution

Cryo-EM structure of Mycobacterium tuberculosis ATP bound FtsEX/RipC complex in peptidisc

Released:
DOI: 10.2210/pdb8idd/pdb
PDB entry 8idd coloured by chain, front view.
PDB entry 8idd coloured by chain, side view.
PDB entry 8idd coloured by chain, top view.
Source organism: Mycobacterium tuberculosis
Primary publication:
Regulation of the cell division hydrolase RipC by the FtsEX system in Mycobacterium tuberculosis.
Li J, Xu X, Shi J, Hermoso JA, Sham LT, Luo M
Nat Commun 14 7999 (2023)
PMID: 38044344
Related structures: EMD-35364

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
PDBe Complex ID:
PDB-CPX-240178 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Cell division ATP-binding protein FtsE Chains: A, B
Molecule details ›
Chains: A, B
Length: 230 amino acids
Theoretical weight: 25.77 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
  • Canonical: O05779 (Residues: 1-230; Coverage: 100%)
Gene names: P425_03233, RVBD_3102c, Rv3102c, ftsE
Sequence domains: ABC transporter
Cell division protein FtsX Chains: C, D
Molecule details ›
Chains: C, D
Length: 297 amino acids
Theoretical weight: 32.85 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
  • Canonical: P9WG19 (Residues: 1-297; Coverage: 100%)
Gene names: MTCY164.12c, Rv3101c, ftsX
Sequence domains:
Probable endopeptidase Rv2190c Chain: E
Molecule details ›
Chain: E
Length: 385 amino acids
Theoretical weight: 39.79 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
  • Canonical: P9WHU3 (Residues: 1-385; Coverage: 100%)
Gene names: MTCY190.01c, MTV021.23c, Rv2190c
Sequence domains: NlpC/P60 family

Ligands and Environments

1 bound ligand:
Ligand ATP 2 x ATP
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4Å
Relevant EMDB volumes: EMD-35364
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'

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