› 8ien

Electron Microscopy
3.25Å resolution

Cryo-EM structure of ATP13A2 in the E2-Pi state

Released:
DOI: 10.2210/pdb8ien/pdb
PDB entry 8ien coloured by chain, front view.
PDB entry 8ien coloured by chain, side view.
PDB entry 8ien coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Conformational cycle of human polyamine transporter ATP13A2.
Mu J, Xue C, Fu L, Yu Z, Nie M, Wu M, Chen X, Liu K, Bu R, Huang Y, Yang B, Han J, Jiang Q, Chan KC, Zhou R, Li H, Huang A, Wang Y, Liu Z
Nat Commun 14 1978 (2023)
PMID: 37031211
Related structures: EMD-35387

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192494 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Polyamine-transporting ATPase 13A2 Chain: P
Molecule details ›
Chain: P
Length: 1180 amino acids
Theoretical weight: 128.91 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9NQ11 (Residues: 1-1180; Coverage: 100%)
Gene names: ATP13A2, PARK9
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand MG 1 x MG
Ligand ALF 1 x ALF
Ligand SPM 2 x SPM
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.25Å
Relevant EMDB volumes: EMD-35387
Expression system: Homo sapiens

Quick links

Citations

1 review citation

P-type ATPases: Many more enigmas left to solve.
Palmgren M. (2023)