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Electron Microscopy
2.55Å resolution

Cryo-EM structure of SARS-CoV-2 Omicron BA.4/5 spike protein in complex with white-tailed deer ACE2

Released:

Function and Biology Details

Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
PDBe Complex ID:
PDB-CPX-227532 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Spike glycoprotein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 1127 amino acids
Theoretical weight: 125.15 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 28-1145; Coverage: 89%)
Gene names: 2, S
Sequence domains:
Angiotensin-converting enzyme Chains: E, F
Molecule details ›
Chains: E, F
Length: 661 amino acids
Theoretical weight: 76.53 KDa
Source organism: Odocoileus virginianus
Expression system: Homo sapiens
UniProt:
  • Canonical: A0A6J0Z472 (Residues: 19-679; Coverage: 100%)
Gene name: ACE2
Sequence domains: Angiotensin-converting enzyme

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.55Å
Relevant EMDB volumes: EMD-35426
Expression system: Homo sapiens