› 8iiu

X-ray diffraction
1.27Å resolution

anti-VEGF nanobody

Released:
DOI: 10.2210/pdb8iiu/pdb
PDB entry 8iiu coloured by chain, front view.
PDB entry 8iiu coloured by chain, side view.
PDB entry 8iiu coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Polymorphic nanobody crystals as long-acting intravitreal therapy for wet age-related macular degeneration.
Zhu S, Fan S, Tang T, Huang J, Zhou H, Huang C, Chen Y, Qian F
OpenAccess logo Bioeng Transl Med 8 e10523 (2023)
PMID: 38023710

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-237653 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
anti-VEGF nanobody Chains: A, B
Molecule details ›
Chains: A, B
Length: 126 amino acids
Theoretical weight: 13.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli

Ligands and Environments

1 bound ligand:
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL18U1
Spacegroup: P1
Unit cell:
a: 31.468Å b: 39.369Å c: 39.952Å
α: 102.14° β: 90.23° γ: 90.95°
R-values:
R R work R free
0.168 0.167 0.187
Expression system: Escherichia coli

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