› 8ijr

Electron Microscopy
3.29Å resolution

The cryo-EM structure of human sphingomyelin synthase-related protein in complex with diacylglycerol/phosphoethanolamine

Released:
DOI: 10.2210/pdb8ijr/pdb
PDB entry 8ijr coloured by chain, front view.
PDB entry 8ijr coloured by chain, side view.
PDB entry 8ijr coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structure of human sphingomyelin synthase and its mechanistic implications for sphingomyelin synthesis.
Hu K, Zhang Q, Chen Y, Yang J, Xia Y, Rao B, Li S, Shen Y, Cao M, Lu H, Qin A, Jiang XC, Yao D, Zhao J, Zhou L, Cao Y
Nat Struct Mol Biol (2024)
PMID: 38388831
Related structures: EMD-35493

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-240553 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sphingomyelin synthase-related protein 1 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 415 amino acids
Theoretical weight: 48.37 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q96LT4 (Residues: 1-415; Coverage: 100%)
Gene name: SAMD8
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand Z0P 6 x Z0P
Ligand OPE 2 x OPE
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.29Å
Relevant EMDB volumes: EMD-35493
Expression system: Homo sapiens

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