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Cryo-EM structure of the gastric proton pump with bound DQ-18

Source organism: Sus scrofa
Biochemical function: protein binding
Biological process: potassium ion import across plasma membrane
Cellular component: apical plasma membrane

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EC 7.2.2.19: H(+)/K(+)-exchanging ATPase

Reaction catalysed:
ATP + H(2)O + H(+)(Side 1) + K(+)(Side 2) = ADP + phosphate + H(+)(Side 2) + K(+)(Side 1)
Systematic name:
ATP phosphohydrolase (P-type,H(+)/K(+)-exchanging)
Alternative Name(s):
  • (K(+) + H(+))-ATPase
  • Gastric H(+)/K(+) ATPase
  • H(+)-K(+)-ATPase
  • H(+)/K(+)-ATPase
  • H,K-ATPase
  • Potassium-transporting ATPase
  • Proton pump

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00287
Domain description: Sodium / potassium ATPase beta chain
Occurring in:
  1. Potassium-transporting ATPase subunit beta
The deposited structure of PDB entry 8ijx contains 1 copy of Pfam domain PF00287 (Sodium / potassium ATPase beta chain) in Potassium-transporting ATPase subunit beta. Showing 1 copy in chain B.

PF00689
Domain description: Cation transporting ATPase, C-terminus
Occurring in:
  1. Potassium-transporting ATPase alpha chain 1
The deposited structure of PDB entry 8ijx contains 1 copy of Pfam domain PF00689 (Cation transporting ATPase, C-terminus) in Sodium/potassium-transporting ATPase subunit alpha. Showing 1 copy in chain A.

PF00702
Domain description: haloacid dehalogenase-like hydrolase
Occurring in:
  1. Potassium-transporting ATPase alpha chain 1
The deposited structure of PDB entry 8ijx contains 1 copy of Pfam domain PF00702 (haloacid dehalogenase-like hydrolase) in Sodium/potassium-transporting ATPase subunit alpha. Showing 1 copy in chain A.

PF13246
Domain description: Cation transport ATPase (P-type)
Occurring in:
  1. Potassium-transporting ATPase alpha chain 1
The deposited structure of PDB entry 8ijx contains 1 copy of Pfam domain PF13246 (Cation transport ATPase (P-type)) in Sodium/potassium-transporting ATPase subunit alpha. Showing 1 copy in chain A.

PF00122
Domain description: E1-E2 ATPase
Occurring in:
  1. Potassium-transporting ATPase alpha chain 1
The deposited structure of PDB entry 8ijx contains 1 copy of Pfam domain PF00122 (E1-E2 ATPase) in Sodium/potassium-transporting ATPase subunit alpha. Showing 1 copy in chain A.

PF00690
Domain description: Cation transporter/ATPase, N-terminus
Occurring in:
  1. Potassium-transporting ATPase alpha chain 1
The deposited structure of PDB entry 8ijx contains 1 copy of Pfam domain PF00690 (Cation transporter/ATPase, N-terminus) in Sodium/potassium-transporting ATPase subunit alpha. Showing 1 copy in chain A.

PF09040
Domain description: Gastric H+/K+-ATPase, N terminal domain
Occurring in:
  1. Potassium-transporting ATPase alpha chain 1
The deposited structure of PDB entry 8ijx contains 1 copy of Pfam domain PF09040 (Gastric H+/K+-ATPase, N terminal domain) in Sodium/potassium-transporting ATPase subunit alpha. Showing 1 copy in chain A (this domain is out of the observed residue ranges!).

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