› 8ilz

X-ray diffraction
1.77Å resolution

Crystal structure of the RRM domain of human SETD1B

Released:
DOI: 10.2210/pdb8ilz/pdb
PDB entry 8ilz coloured by chain, front view.
PDB entry 8ilz coloured by chain, side view.
PDB entry 8ilz coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular insight into the SETD1A/B N-terminal region and its interaction with WDR82.
Bao S, Xu C
Biochem Biophys Res Commun 658 136-140 (2023)
PMID: 37030068

Function and Biology Details

Reaction catalysed: 
S-adenosyl-L-methionine + a [histone H3]-L-lysine(4) = S-adenosyl-L-homocysteine + a [histone H3]-N(6)-methyl-L-lysine(4)
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-577709 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Histone-lysine N-methyltransferase SETD1B Chain: A
Molecule details ›
Chain: A
Length: 103 amino acids
Theoretical weight: 11.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UPS6 (Residues: 102-204; Coverage: 5%)
Gene names: KIAA1076, KMT2G, SET1B, SETD1B
Sequence domains: RNA recognition motif

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL18U1
Spacegroup: P65
Unit cell:
a: 70.575Å b: 70.575Å c: 37.573Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.179 0.177 0.214
Expression system: Escherichia coli

Quick links

Citations

1 citations in other articles

In Vivo and In Vitro Characterization of the RNA Binding Capacity of SETD1A (KMT2F).
Amin et al. (2023)