› 8inz

Electron Microscopy
2.72Å resolution

Cryo-EM structure of human HCN3 channel in apo state

Released:
DOI: 10.2210/pdb8inz/pdb
PDB entry 8inz coloured by chain, front view.
PDB entry 8inz coloured by chain, side view.
PDB entry 8inz coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structure of human HCN3 channel and its regulation by cAMP.
Yu B, Lu Q, Li J, Cheng X, Hu H, Li Y, Che T, Hua Y, Jiang H, Zhang Y, Xian C, Yang T, Fu Y, Chen Y, Nan W, McCormick PJ, Xiong B, Duan J, Zeng B, Li Y, Fu Y, Zhang J
OpenAccess logo J Biol Chem 300 107288 (2024)
PMID: 38636662
Related structures: EMD-35602

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-242923 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 774 amino acids
Theoretical weight: 86.14 KDa
Source organism: Homo sapiens
Expression system: Mammalian expression vector BsrGI-MCS-pcDNA3.1
UniProt:
  • Canonical: Q9P1Z3 (Residues: 1-774; Coverage: 100%)
Gene names: HCN3, KIAA1535
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand VX9 4 x VX9
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.72Å
Relevant EMDB volumes: EMD-35602
Expression system: Mammalian expression vector BsrGI-MCS-pcDNA3.1

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