› 8iow

Electron Microscopy
3.2Å resolution

Cryo-EM structure of the sarilumab Fab/IL-6R complex

Released:
DOI: 10.2210/pdb8iow/pdb
PDB entry 8iow coloured by chain, front view.
PDB entry 8iow coloured by chain, side view.
PDB entry 8iow coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: She J, Chen L, Wang MX
Related structures: EMD-35627

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-241891 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Soluble interleukin-6 receptor subunit alpha Chains: D2, I
Molecule details ›
Chains: D2, I
Length: 365 amino acids
Theoretical weight: 40.28 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P08887 (Residues: 1-355; Coverage: 75%)
  • Best match: P08887-2 (Residues: 1-365)
Gene name: IL6R
Sequence domains:
Light chain of Sarilumab Fab Chain: L
Molecule details ›
Chain: L
Length: 214 amino acids
Theoretical weight: 23.25 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Heavy chain of Sarilumab Fab Chain: H
Molecule details ›
Chain: H
Length: 223 amino acids
Theoretical weight: 23.83 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

1 bound ligand:
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.2Å
Relevant EMDB volumes: EMD-35627
Expression system: Homo sapiens

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