8iue

Electron Microscopy
4.1Å resolution

RNA polymerase III pre-initiation complex melting complex 1

Released:
Source organism: Homo sapiens
Related structures: EMD-35719

Function and Biology Details

Reaction catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
hetero 25-mer (preferred)
PDBe Complex ID:
PDB-CPX-216142 (preferred)
Entry contents:
23 distinct polypeptide molecules
2 distinct DNA molecules
Macromolecules (25 distinct):
DNA-directed RNA polymerase III subunit RPC1 Chain: A
Molecule details ›
Chain: A
Length: 1390 amino acids
Theoretical weight: 155.86 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O14802 (Residues: 1-1390; Coverage: 100%)
Gene name: POLR3A
Sequence domains:
DNA-directed RNA polymerase III subunit RPC2 Chain: B
Molecule details ›
Chain: B
Length: 1133 amino acids
Theoretical weight: 127.95 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9NW08 (Residues: 1-1133; Coverage: 100%)
Gene name: POLR3B
Sequence domains:
DNA-directed RNA polymerases I and III subunit RPAC1 Chain: C
DNA-directed RNA polymerase III subunit RPC9 Chain: D
DNA-directed RNA polymerases I, II, and III subunit RPABC1 Chain: E
DNA-directed RNA polymerases I, II, and III subunit RPABC2 Chain: F
DNA-directed RNA polymerase III subunit RPC8 Chain: G
DNA-directed RNA polymerases I, II, and III subunit RPABC3 Chain: H
DNA-directed RNA polymerase III subunit RPC10 Chain: I
DNA-directed RNA polymerases I, II, and III subunit RPABC5 Chain: J
DNA-directed RNA polymerases I and III subunit RPAC2 Chain: K
DNA-directed RNA polymerases I, II, and III subunit RPABC4 Chain: L
DNA-directed RNA polymerase III subunit RPC5 Chain: M
DNA-directed RNA polymerase III subunit RPC4 Chain: N
DNA-directed RNA polymerase III subunit RPC3 Chain: O
DNA-directed RNA polymerase III subunit RPC6 Chain: P
DNA-directed RNA polymerase III subunit RPC7 Chain: Q
snRNA-activating protein complex subunit 1 Chain: 1
snRNA-activating protein complex subunit 3 Chain: 3
snRNA-activating protein complex subunit 4 Chain: 4
TATA-box-binding protein Chain: U
Transcription factor IIIB 50 kDa subunit Chain: V
Transcription factor TFIIIB component B'' homolog Chain: W
Human gene for U 6 RNA Chain: X
DNA (74-MER) Chain: Y

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.1Å
Relevant EMDB volumes: EMD-35719
Expression systems:
  • Homo sapiens
  • Escherichia coli