› 8ix3

Electron Microscopy
3.98Å resolution

Cryo-EM structure of SARS-CoV-2 BA.4/5 spike protein in complex with 1G11 (local refinement)

Released:
DOI: 10.2210/pdb8ix3/pdb
PDB entry 8ix3 coloured by chain, front view.
PDB entry 8ix3 coloured by chain, side view.
PDB entry 8ix3 coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis for broad neutralization of human antibody against Omicron sublineages and evasion by XBB variant.
Sun H, Wang Y, Chen X, Jiang Y, Wang S, Huang Y, Liu L, Li Y, Lan M, Guo H, Yuan Q, Zhang Y, Li T, Yu H, Gu Y, Zhang J, Li S, Zheng Z, Zheng Q, Xia N
J Virol e0113723 (2023)
PMID: 37855619
Related structures: EMD-35788

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-235785 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
light chain of 1G11 Chain: L
Molecule details ›
Chain: L
Length: 107 amino acids
Theoretical weight: 11.63 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
heavy chain of 1G11 Chain: H
Molecule details ›
Chain: H
Length: 125 amino acids
Theoretical weight: 13.77 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Spike protein S1 Chain: G
Molecule details ›
Chain: G
Length: 213 amino acids
Theoretical weight: 23.95 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 333-557; Coverage: 17%)
Gene names: 2, S
Sequence domains: Betacoronavirus spike glycoprotein S1, receptor binding

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.98Å
Relevant EMDB volumes: EMD-35788
Expression systems:
  • Cricetulus griseus
  • Homo sapiens

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