Function and Biology

Pseudomoans aeruginosa Wildtype Ketopantoate Reductase With 3-Methyl-2-oxovalerate at substrate site

Source organism: Pseudomonas aeruginosa
Biochemical function: oxidoreductase activity
Biological process: pantothenate biosynthetic process
Cellular component: cytoplasm

EC 1.1.1.169: 2-dehydropantoate 2-reductase

Reaction catalysed:
(R)-pantoate + NADP(+) = 2-dehydropantoate + NADPH
Systematic name:
(R)-pantoate:NADP(+) 2-oxidoreductase
Alternative Name(s):
  • 2-ketopantoate reductase
  • 2-ketopantoic acid reductase
  • 2-oxopantoate reductase
  • KPA reductase
  • Ketopantoate reductase
  • Ketopantoic acid reductase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF08546
Domain description: Ketopantoate reductase PanE/ApbA C terminal
Occurring in:
  1. 2-dehydropantoate 2-reductase
The deposited structure of PDB entry 8ixh contains 3 copies of Pfam domain PF08546 (Ketopantoate reductase PanE/ApbA C terminal) in 2-dehydropantoate 2-reductase. Showing 1 copy in chain A.

PF02558
Domain description: Ketopantoate reductase PanE/ApbA
Occurring in:
  1. 2-dehydropantoate 2-reductase
The deposited structure of PDB entry 8ixh contains 3 copies of Pfam domain PF02558 (Ketopantoate reductase PanE/ApbA) in 2-dehydropantoate 2-reductase. Showing 1 copy in chain A.