8iyg

Electron Microscopy
2.69Å resolution

Human neuronal gap junction channel connexin 36

Released:
Source organism: Homo sapiens
Primary publication:
Assembly mechanisms of the neuronal gap junction channel connexin 36 elucidated by Cryo-EM.
Arch Biochem Biophys 754 109959 (2024)
PMID: 38490311
Related structures: EMD-35821

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dodecamer (preferred)
PDBe Complex ID:
PDB-CPX-193853 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Gap junction delta-2 protein Chains: A, B, C, D, E, F, G, H, I, J, K, L
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 321 amino acids
Theoretical weight: 36.14 KDa
Source organism: Homo sapiens
Expression system: eukaryotic plasmids
UniProt:
  • Canonical: Q9UKL4 (Residues: 1-321; Coverage: 100%)
Gene names: GJA9, GJD2
Sequence domains: Connexin

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.69Å
Relevant EMDB volumes: EMD-35821
Expression system: eukaryotic plasmids