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cryo-EM structure of sulindac-bound hMRP4

Source organism: Homo sapiens
Biochemical function: ABC-type transporter activity
Biological process: guanine nucleotide transmembrane transport
Cellular component: external side of apical plasma membrane

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EC 7.6.2.3: ABC-type glutathione-S-conjugate transporter

Reaction catalysed:
ATP + H(2)O + glutathione-S-conjugate(Side 1) = ADP + phosphate + glutathione-S-conjugate(Side 2)
Systematic name:
ATP phosphohydrolase (ABC-type, glutathione-S-conjugate-exporting)
Alternative Name(s):
  • ABCC1 (gene name)
  • Glutathione-S-conjugate-translocating ATPase
  • MRP
  • MRP1
  • Multidrug resistance-associated protein 1
  • YBT1 (gene name)
  • YCF1 (gene name)

EC 7.6.2.2: ABC-type xenobiotic transporter

Reaction catalysed:
ATP + H(2)O + xenobiotic(Side 1) = ADP + phosphate + xenobiotic(Side 2)
Systematic name:
ATP phosphohydrolase (ABC-type, xenobiotic-exporting)
Alternative Name(s):
  • ATP phosphohydrolase (steroid-exporting)
  • MDR protein
  • Multidrug-resistance protein
  • P-glycoprotein
  • PDR protein
  • Pleiotropic-drug-resistance protein
  • Steroid-transporting ATPase
  • Xenobiotic-transporting ATPase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF00005
Domain description: ABC transporter
Occurring in:
  1. ATP-binding cassette sub-family C member 4
The deposited structure of PDB entry 8iz7 contains 2 copies of Pfam domain PF00005 (ABC transporter) in ATP-binding cassette sub-family C member 4. Showing 2 copies in chain A.

PF00664
Domain description: ABC transporter transmembrane region
Occurring in:
  1. ATP-binding cassette sub-family C member 4
The deposited structure of PDB entry 8iz7 contains 2 copies of Pfam domain PF00664 (ABC transporter transmembrane region) in ATP-binding cassette sub-family C member 4. Showing 2 copies in chain A.

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