› 8iz9

Electron Microscopy
2.95Å resolution

cryo-EM structure of PGE1-bound hMRP4

Released:
DOI: 10.2210/pdb8iz9/pdb
PDB entry 8iz9 coloured by chain, front view.
PDB entry 8iz9 coloured by chain, side view.
PDB entry 8iz9 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Liu ZM, Huang Y
Related structures: EMD-35836

Function and Biology Details

Reactions catalysed: 
ATP + H(2)O + xenobiotic(Side 1) = ADP + phosphate + xenobiotic(Side 2)
ATP + H(2)O + glutathione-S-conjugate(Side 1) = ADP + phosphate + glutathione-S-conjugate(Side 2)
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-216241 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ATP-binding cassette sub-family C member 4 Chain: A
Molecule details ›
Chain: A
Length: 1357 amino acids
Theoretical weight: 153.17 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O15439 (Residues: 1-1325; Coverage: 100%)
Gene names: ABCC4, MOATB, MRP4
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand XPG 1 x XPG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.95Å
Relevant EMDB volumes: EMD-35836
Expression system: Homo sapiens

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