› 8izb

Electron Microscopy
3.06Å resolution

Lysophosphatidylserine receptor GPR174-Gs complex

Released:
DOI: 10.2210/pdb8izb/pdb
PDB entry 8izb coloured by chain, front view.
PDB entry 8izb coloured by chain, side view.
PDB entry 8izb coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis for ligand recognition and signaling of the lysophosphatidylserine receptors GPR34 and GPR174.
Liu G, Li X, Wang Y, Zhang X, Gong W
OpenAccess logo PLoS Biol 21 e3002387 (2023)
PMID: 38048360
Related structures: EMD-35838

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
PDBe Complex ID:
PDB-CPX-234042 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Chain: A
Molecule details ›
Chain: A
Length: 246 amino acids
Theoretical weight: 29.05 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Chain: B
Molecule details ›
Chain: B
Length: 376 amino acids
Theoretical weight: 40.85 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Chain: C
Nanobody35 Chain: N
Probable G-protein coupled receptor 174 Chain: R

Ligands and Environments

3 bound ligands:
Ligand UBL 1 x UBL
Ligand SER 1 x SER
Ligand CLR 2 x CLR
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.06Å
Relevant EMDB volumes: EMD-35838
Expression systems:
  • Spodoptera frugiperda
  • Escherichia coli

Quick links

Citations

1 citations in other articles

Phosphatidylserine phospholipase A1 enables GPR34-dependent immune cell accumulation in the peritoneal cavity.
Tam et al. (2024)