› 8izn

Electron Microscopy
6.67Å resolution

Structural study of Interferon-induced, double-stranded RNA-activated protein kinase (PKR) and Non-structural protein 1 (NS1) complex

Released:
DOI: 10.2210/pdb8izn/pdb
PDB entry 8izn coloured by chain, front view.
PDB entry 8izn coloured by chain, side view.
PDB entry 8izn coloured by chain, top view.
Source organisms:
Entry authors: Han CW, Kim HJ
Related structures: EMD-35866

Function and Biology Details

Reactions catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-273304 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Interferon-induced, double-stranded RNA-activated protein kinase Chain: A
Molecule details ›
Chain: A
Length: 179 amino acids
Theoretical weight: 19.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P19525 (Residues: 1-170; Coverage: 31%)
Gene names: EIF2AK2, PKR, PRKR
Sequence domains: Double-stranded RNA binding motif
Non-structural protein 1 Chain: B
Molecule details ›
Chain: B
Length: 122 amino acids
Theoretical weight: 13.8 KDa
Source organism: Influenza A virus (A/Memphis/102/1972(H3N2))
Expression system: Escherichia coli
UniProt:
  • Canonical: Q463W9 (Residues: 84-205; Coverage: 56%)
Gene name: NS
Sequence domains: Influenza non-structural protein (NS1)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 6.67Å
Relevant EMDB volumes: EMD-35866
Expression system: Escherichia coli

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