› 8j05

Electron Microscopy
2.7Å resolution

Human KCNQ2-CaM complex in the presence of PIP2

Released:
DOI: 10.2210/pdb8j05/pdb
PDB entry 8j05 coloured by chain, front view.
PDB entry 8j05 coloured by chain, side view.
PDB entry 8j05 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Ligand activation mechanisms of human KCNQ2 channel.
Ma D, Zheng Y, Li X, Zhou X, Yang Z, Zhang Y, Wang L, Zhang W, Fang J, Zhao G, Hou P, Nan F, Yang W, Su N, Gao Z, Guo J
OpenAccess logo Nat Commun 14 6632 (2023)
PMID: 37857637
Related structures: EMD-35884

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-236057 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Potassium voltage-gated channel subfamily KQT member 2 Chains: A, B, D, G
Molecule details ›
Chains: A, B, D, G
Length: 656 amino acids
Theoretical weight: 73.63 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O43526 (Residues: 64-702; Coverage: 73%)
Gene name: KCNQ2
Sequence domains:
Calmodulin-1 Chains: C, E, F, H
Molecule details ›
Chains: C, E, F, H
Length: 177 amino acids
Theoretical weight: 19.62 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DP23 (Residues: 1-149; Coverage: 100%)
Gene names: CALM, CALM1, CAM, CAM1
Sequence domains: EF-hand domain pair

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.7Å
Relevant EMDB volumes: EMD-35884
Expression system: Homo sapiens

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