› 8j0l

X-ray diffraction
1.98Å resolution

Structure of DNA binding Domain of Human TFAP2A

Released:
DOI: 10.2210/pdb8j0l/pdb
PDB entry 8j0l coloured by chain, front view.
PDB entry 8j0l coloured by chain, side view.
PDB entry 8j0l coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for specific DNA sequence motif recognition by the TFAP2 transcription factors.
Liu K, Xiao Y, Gan L, Li W, Zhang J, Min J
OpenAccess logo Nucleic Acids Res (2023)
PMID: 37409559

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-220478 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transcription factor AP-2-alpha Chains: A, B
Molecule details ›
Chains: A, B
Length: 219 amino acids
Theoretical weight: 23.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P05549 (Residues: 202-420; Coverage: 50%)
Gene names: AP2TF, TFAP2, TFAP2A
Sequence domains: Transcription factor AP-2

Ligands and Environments

1 bound ligand:
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL10U2
Spacegroup: P212121
Unit cell:
a: 50.613Å b: 81.907Å c: 115.939Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.184 0.183 0.219
Expression system: Escherichia coli BL21(DE3)

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