› 8j58

Electron Microscopy
3.15Å resolution

Cryo-EM structure of Mycobacterium tuberculosis ATP synthase Fo in the apo-form

Released:
DOI: 10.2210/pdb8j58/pdb
PDB entry 8j58 coloured by chain, front view.
PDB entry 8j58 coloured by chain, side view.
PDB entry 8j58 coloured by chain, top view.
Source organism: Mycobacterium tuberculosis
Primary publication:
Inhibition of M. tuberculosis and human ATP synthase by BDQ and TBAJ-587.
Zhang Y, Lai Y, Zhou S, Ran T, Zhang Y, Zhao Z, Feng Z, Yu L, Xu J, Shi K, Wang J, Pang Y, Li L, Chen H, Guddat LW, Gao Y, Liu F, Rao Z, Gong H
Nature 631 409-414 (2024)
PMID: 38961288
Related structures: EMD-35983

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero decamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-274275 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
ATP synthase subunit c Chains: 1, 2, 3, 4, 5, 6, 7, 8, 9
Molecule details ›
Chains: 1, 2, 3, 4, 5, 6, 7, 8, 9
Length: 81 amino acids
Theoretical weight: 8.06 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Mycolicibacterium smegmatis
UniProt:
  • Canonical: P9WPS1 (Residues: 1-81; Coverage: 100%)
Gene names: MTCY373.25, Rv1305, atpE
Sequence domains: ATP synthase subunit C
ATP synthase subunit a Chain: a
Molecule details ›
Chain: a
Length: 250 amino acids
Theoretical weight: 27.49 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Mycolicibacterium smegmatis
UniProt:
  • Canonical: P9WPV7 (Residues: 1-250; Coverage: 100%)
Gene names: MTCY373.24, Rv1304, atpB
Sequence domains: ATP synthase A chain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.15Å
Relevant EMDB volumes: EMD-35983
Expression system: Mycolicibacterium smegmatis

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