› 8j74

Electron Microscopy
3.6Å resolution

Human high-affinity choline transporter CHT1 in the HC-3-bound outward-facing open conformation, dimeric state

Released:
DOI: 10.2210/pdb8j74/pdb
PDB entry 8j74 coloured by chain, front view.
PDB entry 8j74 coloured by chain, side view.
PDB entry 8j74 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Transport mechanism of presynaptic high-affinity choline uptake by CHT1.
Qiu Y, Gao Y, Huang B, Bai Q, Zhao Y
Nat Struct Mol Biol (2024)
PMID: 38589607
Related structures: EMD-36025

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-242686 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
High affinity choline transporter 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 580 amino acids
Theoretical weight: 63.24 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9GZV3 (Residues: 1-580; Coverage: 100%)
Gene names: CHT1, SLC5A7
Sequence domains: Sodium:solute symporter family

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
4 bound ligands:
Ligand Y01 2 x Y01
Ligand AV0 2 x AV0
Ligand R16 2 x R16
Ligand HC6 2 x HC6
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.6Å
Relevant EMDB volumes: EMD-36025
Expression system: Homo sapiens

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