› 8j8j

Electron Microscopy
2.76Å resolution

Membrane bound PRTase, C3 symmetry, donor bound

Released:
DOI: 10.2210/pdb8j8j/pdb
PDB entry 8j8j coloured by chain, front view.
PDB entry 8j8j coloured by chain, side view.
PDB entry 8j8j coloured by chain, top view.
Source organism: Mycobacterium tuberculosis H37Rv
Primary publication:
Structural analysis of phosphoribosyltransferase-mediated cell wall precursor synthesis in Mycobacterium tuberculosis.
Gao S, Wu F, Gurcha SS, Batt SM, Besra GS, Rao Z, Zhang L
OpenAccess logo Nat Microbiol (2024)
PMID: 38491273
Related structures: EMD-36071

Function and Biology Details

Reaction catalysed: 
Trans,octacis-decaprenyl phosphate + 5-phospho-alpha-D-ribose 1-diphosphate = trans,octacis-decaprenylphospho-beta-D-ribofuranose 5-phosphate + diphosphate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-239701 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Decaprenyl-phosphate phosphoribosyltransferase Chains: A, B, D
Molecule details ›
Chains: A, B, D
Length: 302 amino acids
Theoretical weight: 32.68 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Mycolicibacterium smegmatis MC2 155
UniProt:
  • Canonical: P9WFR5 (Residues: 1-302; Coverage: 100%)
Gene name: Rv3806c
Sequence domains: UbiA prenyltransferase family

Ligands and Environments

3 bound ligands:
Ligand PRP 3 x PRP
Ligand MG 3 x MG
Ligand PGW 3 x PGW
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.76Å
Relevant EMDB volumes: EMD-36071
Expression system: Mycolicibacterium smegmatis MC2 155

Quick links