8j9i

Electron Microscopy
2.87Å resolution

Cryo-EM structure of Euglena gracilis complex I, turnover state

Released:
Source organism: Euglena gracilis
Related structures: EMD-36108

Function and Biology Details

Reaction catalysed:
NADH + ubiquinone + 5 H(+)(Side 1) = NAD(+) + ubiquinol + 4 H(+)(Side 2)
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero 61-mer (preferred)
PDBe Complex ID:
PDB-CPX-240374 (preferred)
Entry contents:
59 distinct polypeptide molecules
Macromolecules (59 distinct):
NDUFS1A Chain: 1A
Molecule details ›
Chain: 1A
Length: 385 amino acids
Theoretical weight: 43.89 KDa
Source organism: Euglena gracilis
NDUFS1B Chain: 1B
Molecule details ›
Chain: 1B
Length: 527 amino acids
Theoretical weight: 59.67 KDa
Source organism: Euglena gracilis
ND2B Chain: 2B
Molecule details ›
Chain: 2B
Length: 142 amino acids
Theoretical weight: 15.76 KDa
Source organism: Euglena gracilis
ND4L Chain: 4L
Molecule details ›
Chain: 4L
Length: 171 amino acids
Theoretical weight: 19.67 KDa
Source organism: Euglena gracilis
NDUFA1 Chain: A1
Molecule details ›
Chain: A1
Length: 141 amino acids
Theoretical weight: 15.66 KDa
Source organism: Euglena gracilis
NDUFA2 Chain: A2
Molecule details ›
Chain: A2
Length: 193 amino acids
Theoretical weight: 21.33 KDa
Source organism: Euglena gracilis
NDUFA3 Chain: A3
Molecule details ›
Chain: A3
Length: 125 amino acids
Theoretical weight: 14.95 KDa
Source organism: Euglena gracilis
NDUFA5 Chain: A5
Molecule details ›
Chain: A5
Length: 184 amino acids
Theoretical weight: 20.96 KDa
Source organism: Euglena gracilis
NDUFA6 Chain: A6
Molecule details ›
Chain: A6
Length: 437 amino acids
Theoretical weight: 48.79 KDa
Source organism: Euglena gracilis
NDUFA7 Chain: A7
Molecule details ›
Chain: A7
Length: 136 amino acids
Theoretical weight: 16.36 KDa
Source organism: Euglena gracilis
NDUFA8 Chain: A8
Molecule details ›
Chain: A8
Length: 223 amino acids
Theoretical weight: 25.92 KDa
Source organism: Euglena gracilis
NDUFA9 Chain: A9
Molecule details ›
Chain: A9
Length: 489 amino acids
Theoretical weight: 54.98 KDa
Source organism: Euglena gracilis
NDUFAB1-alpha Chain: AB
Molecule details ›
Chain: AB
Length: 134 amino acids
Theoretical weight: 14.94 KDa
Source organism: Euglena gracilis
NDUFAB1-beta Chain: AC
Molecule details ›
Chain: AC
Length: 134 amino acids
Theoretical weight: 14.9 KDa
Source organism: Euglena gracilis
NDUFA12 Chain: AL
Molecule details ›
Chain: AL
Length: 281 amino acids
Theoretical weight: 33.34 KDa
Source organism: Euglena gracilis
NDUFA13 Chain: AM
Molecule details ›
Chain: AM
Length: 198 amino acids
Theoretical weight: 22.68 KDa
Source organism: Euglena gracilis
NDUFA11 Chain: AN
Molecule details ›
Chain: AN
Length: 287 amino acids
Theoretical weight: 32.62 KDa
Source organism: Euglena gracilis
NDUFB2 Chain: B2
Molecule details ›
Chain: B2
Length: 145 amino acids
Theoretical weight: 17.2 KDa
Source organism: Euglena gracilis
NDUFB3 Chain: B3
Molecule details ›
Chain: B3
Length: 62 amino acids
Theoretical weight: 6.83 KDa
Source organism: Euglena gracilis
NDUFB4 Chain: B4
Molecule details ›
Chain: B4
Length: 171 amino acids
Theoretical weight: 19.51 KDa
Source organism: Euglena gracilis
NDUFB5 Chain: B5
Molecule details ›
Chain: B5
Length: 140 amino acids
Theoretical weight: 15.82 KDa
Source organism: Euglena gracilis
NDUFB6 Chain: B6
Molecule details ›
Chain: B6
Length: 91 amino acids
Theoretical weight: 10.93 KDa
Source organism: Euglena gracilis
NDUFB7 Chain: B7
Molecule details ›
Chain: B7
Length: 97 amino acids
Theoretical weight: 12.25 KDa
Source organism: Euglena gracilis
NDUFB8 Chain: B8
Molecule details ›
Chain: B8
Length: 176 amino acids
Theoretical weight: 20.49 KDa
Source organism: Euglena gracilis
NDUFB9 Chain: B9
Molecule details ›
Chain: B9
Length: 158 amino acids
Theoretical weight: 18.35 KDa
Source organism: Euglena gracilis
NDUFB10 Chain: BL
Molecule details ›
Chain: BL
Length: 144 amino acids
Theoretical weight: 17.47 KDa
Source organism: Euglena gracilis
NDUFB11 Chain: BM
Molecule details ›
Chain: BM
Length: 112 amino acids
Theoretical weight: 13.05 KDa
Source organism: Euglena gracilis
NDUFC2 Chain: C4
Molecule details ›
Chain: C4
Length: 185 amino acids
Theoretical weight: 22.01 KDa
Source organism: Euglena gracilis
NDUEG1 Chain: E1
Molecule details ›
Chain: E1
Length: 483 amino acids
Theoretical weight: 53.35 KDa
Source organism: Euglena gracilis
NDUEG2 Chain: E2
Molecule details ›
Chain: E2
Length: 467 amino acids
Theoretical weight: 50.52 KDa
Source organism: Euglena gracilis
NDUEG3 Chain: E3
Molecule details ›
Chain: E3
Length: 434 amino acids
Theoretical weight: 46.41 KDa
Source organism: Euglena gracilis
NDUEG4 Chain: E4
Molecule details ›
Chain: E4
Length: 368 amino acids
Theoretical weight: 41.31 KDa
Source organism: Euglena gracilis
NDUEG5 Chain: E5
Molecule details ›
Chain: E5
Length: 290 amino acids
Theoretical weight: 29.18 KDa
Source organism: Euglena gracilis
NDUEG6 Chain: E6
Molecule details ›
Chain: E6
Length: 371 amino acids
Theoretical weight: 43.67 KDa
Source organism: Euglena gracilis
NDUEG8 Chain: E8
Molecule details ›
Chain: E8
Length: 205 amino acids
Theoretical weight: 23.99 KDa
Source organism: Euglena gracilis
NDUEG10 Chain: EA
Molecule details ›
Chain: EA
Length: 126 amino acids
Theoretical weight: 14.14 KDa
Source organism: Euglena gracilis
NDUEG11 Chain: EB
Molecule details ›
Chain: EB
Length: 101 amino acids
Theoretical weight: 11.47 KDa
Source organism: Euglena gracilis
NDUEG12 Chain: EC
Molecule details ›
Chain: EC
Length: 101 amino acids
Theoretical weight: 11.32 KDa
Source organism: Euglena gracilis
NDUEG13 Chain: ED
Molecule details ›
Chain: ED
Length: 151 amino acids
Theoretical weight: 17.73 KDa
Source organism: Euglena gracilis
NDUFX Chain: FX
Molecule details ›
Chain: FX
Length: 325 amino acids
Theoretical weight: 37.2 KDa
Source organism: Euglena gracilis
NDUCA1 Chain: G1
Molecule details ›
Chain: G1
Length: 436 amino acids
Theoretical weight: 48.73 KDa
Source organism: Euglena gracilis
NDUCA2 Chain: G2
Molecule details ›
Chain: G2
Length: 267 amino acids
Theoretical weight: 28.86 KDa
Source organism: Euglena gracilis
NDUCA3 Chain: G3
Molecule details ›
Chain: G3
Length: 261 amino acids
Theoretical weight: 28.02 KDa
Source organism: Euglena gracilis
ND1 Chain: N1
Molecule details ›
Chain: N1
Length: 670 amino acids
Theoretical weight: 79.68 KDa
Source organism: Euglena gracilis
ND2A Chain: N2
Molecule details ›
Chain: N2
Length: 300 amino acids
Theoretical weight: 35.86 KDa
Source organism: Euglena gracilis
ND3 Chains: N3, N6
Molecule details ›
Chains: N3, N6
Length: 293 amino acids
Theoretical weight: 34.5 KDa
Source organism: Euglena gracilis
NADH-ubiquinone oxidoreductase chain 4 Chain: N4
Molecule details ›
Chain: N4
Length: 478 amino acids
Theoretical weight: 56.42 KDa
Source organism: Euglena gracilis
UniProt:
  • Canonical: A0A0S2YRV6 (Residues: 1-478; Coverage: 100%)
Gene name: nad4
Sequence domains: Proton-conducting membrane transporter
ND5 Chain: N5
Molecule details ›
Chain: N5
Length: 584 amino acids
Theoretical weight: 68.38 KDa
Source organism: Euglena gracilis
NDUFS2 Chain: S2
Molecule details ›
Chain: S2
Length: 395 amino acids
Theoretical weight: 45.25 KDa
Source organism: Euglena gracilis
NDUFS3 Chain: S3
Molecule details ›
Chain: S3
Length: 277 amino acids
Theoretical weight: 32.47 KDa
Source organism: Euglena gracilis
NDUFS4 Chain: S4
Molecule details ›
Chain: S4
Length: 208 amino acids
Theoretical weight: 23.74 KDa
Source organism: Euglena gracilis
NDUFS5 Chain: S5
Molecule details ›
Chain: S5
Length: 122 amino acids
Theoretical weight: 14.24 KDa
Source organism: Euglena gracilis
NDUFS6 Chain: S6
Molecule details ›
Chain: S6
Length: 147 amino acids
Theoretical weight: 17.1 KDa
Source organism: Euglena gracilis
NDUFS7 Chain: S7
Molecule details ›
Chain: S7
Length: 207 amino acids
Theoretical weight: 22.84 KDa
Source organism: Euglena gracilis
NDUFS8 Chain: S8
Molecule details ›
Chain: S8
Length: 212 amino acids
Theoretical weight: 24.37 KDa
Source organism: Euglena gracilis
UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK Chains: U1, U2
Molecule details ›
Chains: U1, U2
Length: 12 amino acids
Theoretical weight: 1.04 KDa
Source organism: Euglena gracilis
NDUFV1 Chain: V1
Molecule details ›
Chain: V1
Length: 526 amino acids
Theoretical weight: 57.94 KDa
Source organism: Euglena gracilis
NDUFV2 Chain: V2
Molecule details ›
Chain: V2
Length: 225 amino acids
Theoretical weight: 25.19 KDa
Source organism: Euglena gracilis
NDUEG7 Chain: E7
Molecule details ›
Chain: E7
Length: 246 amino acids
Theoretical weight: 26.82 KDa
Source organism: Euglena gracilis

Ligands and Environments

Experiments and Validation Details

Entry percentile scores
Resolution: 2.87Å
Relevant EMDB volumes: EMD-36108