› 8j9m

X-ray diffraction
2.9Å resolution

Crystal Structure of Human H-Ferritin variant 123F assembling in solution3

Released:
DOI: 10.2210/pdb8j9m/pdb
PDB entry 8j9m coloured by chain, front view.
PDB entry 8j9m coloured by chain, side view.
PDB entry 8j9m coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Shape-Anisotropic Assembly of Protein Nanocages with Identical Building Blocks by Designed Intermolecular π-π Interactions.
Chen X, Zhang T, Liu H, Zang J, Lv C, Du M, Zhao G
OpenAccess logo Adv Sci (Weinh) 10 e2305398 (2023)
PMID: 37870198

Function and Biology Details

Reaction catalysed: 
4 Fe(2+) + 4 H(+) + O(2) = 4 Fe(3+) + 2 H(2)O
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo 24-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-526971 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ferritin heavy chain Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 183 amino acids
Theoretical weight: 21.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02794 (Residues: 1-183; Coverage: 100%)
Gene names: FTH, FTH1, FTHL6, OK/SW-cl.84, PIG15
Sequence domains: Ferritin-like domain

Ligands and Environments

1 bound ligand:
Ligand FE 8 x FE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL18U1
Spacegroup: I422
Unit cell:
a: 143.331Å b: 143.331Å c: 166.663Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.205 0.203 0.243
Expression system: Escherichia coli

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Citations

1 citations in other articles

Shape-Anisotropic Assembly of Protein Nanocages with Identical Building Blocks by Designed Intermolecular π-π Interactions.
Chen et al. (2023)