› 8ja5

X-ray diffraction
2.79Å resolution

Crystal structure of Nipah Virus attachment (G) glycoprotein in complex with neutralizing antibody 14F8

Released:
DOI: 10.2210/pdb8ja5/pdb
PDB entry 8ja5 coloured by chain, front view.
PDB entry 8ja5 coloured by chain, side view.
PDB entry 8ja5 coloured by chain, top view.
Source organism: Mus musculus
Entry authors: Li YH, Huang XY, Xu JJ, Chen W

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-244277 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (8 distinct):
14F8 antibody heavy chain Chains: B, H
Molecule details ›
Chains: B, H
Length: 233 amino acids
Theoretical weight: 24.97 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
14F8 antibody light chain Chain: L
Molecule details ›
Chain: L
Length: 216 amino acids
Theoretical weight: 23.59 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
Glycoprotein G Chains: A, D
Molecule details ›
Chains: A, D
Length: 423 amino acids
Theoretical weight: 47.76 KDa
UniProt:
  • Canonical: Q9IH62 (Residues: 186-602; Coverage: 69%)
Gene name: G
Sequence domains: Haemagglutinin-neuraminidase
14F8 antibody light chain Chain: C
Molecule details ›
Chain: C
Length: 219 amino acids
Theoretical weight: 24.08 KDa
Source organism: Mus musculus
Expression system: Homo sapiens

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN, FUC
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN, FUC
Carbohydrate polymer
1 bound ligand:
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL02U1
Spacegroup: P41212
Unit cell:
a: 125.957Å b: 125.957Å c: 317.264Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.218 0.217 0.245
Expression system: Homo sapiens

Quick links