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Neurokinin B bound to active human neurokinin 3 receptor in complex with Gq

Electron Microscopy
2.8Å resolution
PDB entry 8jbg coloured by chain, front view.
PDB entry 8jbg coloured by chain, side view.
PDB entry 8jbg coloured by chain, top view.
Source organisms:
Assembly composition:
hetero hexamer (preferred)
Entry contents: 6 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero hexamer
Accessible surface area: 47130.01 Å2
Buried surface area: 12306.77 Å2
Dissociation area: 1,835.54 Å2
Dissociation energy (ΔGdiss): -6.78 kcal/mol
Dissociation entropy (TΔSdiss): 27.12 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-276190

Macromolecules

Neuromedin-K receptor
Chain: B
Length: 1428 amino acids
Theoretical weight: 158.09 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
Neuromedin-K receptor (NK3R-pFastbac1) in PDB entry 8jbg, assembly 1, front view.
Neuromedin-K receptor (NK3R-pFastbac1) in PDB entry 8jbg, assembly 1, side view.
Neuromedin-K receptor (NK3R-pFastbac1) in PDB entry 8jbg, assembly 1, top view.
114282004006008001,0001,2001,400
 
5001000
UniProt
P29371
Chains
Interaction interfaces
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Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Chain: D
Length: 377 amino acids
Theoretical weight: 41.06 KDa
Source organism: Rattus norvegicus
Expression system: Spodoptera frugiperda
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 8jbg, assembly 1, front view.
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 8jbg, assembly 1, side view.
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 8jbg, assembly 1, top view.
137750100150200250300350
 
100200300
UniProt
P54311
Chains
Interaction interfaces
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ScFv16 nanobody
Chain: E
Length: 304 amino acids
Theoretical weight: 32.71 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
ScFv16 nanobody in PDB entry 8jbg, assembly 1, front view.
ScFv16 nanobody in PDB entry 8jbg, assembly 1, side view.
ScFv16 nanobody in PDB entry 8jbg, assembly 1, top view.
130420406080100120140160180200220240260280300
 
100200300
Chains
Chain C (auth E)
Interaction interfaces
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Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Chain: G
Length: 71 amino acids
Theoretical weight: 7.86 KDa
Source organism: Bos taurus
Expression system: Spodoptera frugiperda
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 8jbg, assembly 1, front view.
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 8jbg, assembly 1, side view.
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 8jbg, assembly 1, top view.
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Neurokinin-B
Chain: A
Length: 10 amino acids
Theoretical weight: 1.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Neurokinin-B in PDB entry 8jbg, assembly 1, front view.
Neurokinin-B in PDB entry 8jbg, assembly 1, side view.
Neurokinin-B in PDB entry 8jbg, assembly 1, top view.
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Guanine nucleotide-binding protein Gq (G324)
Chain: C
Length: 361 amino acids
Theoretical weight: 41.69 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
Guanine nucleotide-binding protein Gq (G324) in PDB entry 8jbg, assembly 1, front view.
Guanine nucleotide-binding protein Gq (G324) in PDB entry 8jbg, assembly 1, side view.
Guanine nucleotide-binding protein Gq (G324) in PDB entry 8jbg, assembly 1, top view.
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