8jce

Electron Microscopy
2.41Å resolution

Cryo-EM Structure of Chikungunya Virus Nonstructural Protein 1 with m7GpppAmU

Released:

Function and Biology Details

Reactions catalysed:
ATP + RNA(n) = diphosphate + RNA(n+1)
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
ADP-D-ribose 1''-phosphate + H(2)O = ADP-D-ribose + phosphate
NTP + H(2)O = NDP + phosphate
A 5'-triphospho-[mRNA] + H(2)O = a 5'-diphospho-[mRNA] + phosphate
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dodecamer (preferred)
PDBe Complex ID:
PDB-CPX-185035 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
mRNA-capping enzyme nsP1 Chains: A, B, C, D, E, F, G, H, I, J, K, L
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 552 amino acids
Theoretical weight: 61.99 KDa
Source organism: Chikungunya virus strain S27-African prototype
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8JUX6 (Residues: 1-516; Coverage: 21%)
Sequence domains: Viral methyltransferase

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.41Å
Relevant EMDB volumes: EMD-36159
Expression system: Homo sapiens