› 8jen

X-ray diffraction
2.71Å resolution

Crystal structure of TIGIT in complexed with Ociperlimab, crystal form II

Released:
DOI: 10.2210/pdb8jen/pdb
PDB entry 8jen coloured by chain, front view.
PDB entry 8jen coloured by chain, side view.
PDB entry 8jen coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into the unique pH-responsive characteristics of the anti-TIGIT therapeutic antibody Ociperlimab.
Sun J, Zhang X, Xue L, Cheng L, Zhang J, Chen X, Shen Z, Li K, Wang L, Huang C, Song J
Structure (2024)
PMID: 38460520

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-274720 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
antibody heavy chain Chains: A, C, E, G
Molecule details ›
Chains: A, C, E, G
Length: 222 amino acids
Theoretical weight: 23.78 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
antibody light chain Chains: B, D, F, H
Molecule details ›
Chains: B, D, F, H
Length: 214 amino acids
Theoretical weight: 23.3 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
T-cell immunoreceptor with Ig and ITIM domains Chains: I, J, M, P
Molecule details ›
Chains: I, J, M, P
Length: 115 amino acids
Theoretical weight: 12.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q495A1 (Residues: 22-128; Coverage: 48%)
Gene names: TIGIT, VSIG9, VSTM3
Sequence domains: Immunoglobulin V-set domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL45XU
Spacegroup: P21
Unit cell:
a: 100.32Å b: 79.35Å c: 173.69Å
α: 90° β: 101.67° γ: 90°
R-values:
R R work R free
0.221 0.218 0.289
Expression systems:
  • Homo sapiens
  • Escherichia coli

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