› 8jex

Electron Microscopy
3.1Å resolution

Cryo-EM structure of alpha-synuclein gS87 fibril

Released:
DOI: 10.2210/pdb8jex/pdb
PDB entry 8jex coloured by chain, front view.
PDB entry 8jex coloured by chain, side view.
PDB entry 8jex coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Phosphorylation and O-GlcNAcylation at the same α-synuclein site generate distinct fibril structures.
Hu J, Xia W, Zeng S, Lim YJ, Tao Y, Sun Y, Zhao L, Wang H, Le W, Li D, Zhang S, Liu C, Li YM
OpenAccess logo Nat Commun 15 2677 (2024)
PMID: 38538591
Related structures: EMD-36202

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dodecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-273668 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Alpha-synuclein Chains: A, B, G, H, K, P
Molecule details ›
Chains: A, B, G, H, K, P
Length: 140 amino acids
Theoretical weight: 14.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P37840 (Residues: 1-140; Coverage: 100%)
Gene names: NACP, PARK1, SNCA
Sequence domains: Synuclein
unverified amino acid chain Chains: C, D, I, J, L, Q
Molecule details ›
Chains: C, D, I, J, L, Q
Length: 9 amino acids
Theoretical weight: 784 Da
Source organism: Homo sapiens
Expression system: Escherichia coli

Ligands and Environments

1 bound ligand:
Ligand NAG 6 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.1Å
Relevant EMDB volumes: EMD-36202
Expression system: Escherichia coli

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Citations

1 review citation

Glycosylation in aging and neurodegenerative diseases.
Zhang et al. (2024)
3 other articles