› 8jg5

Electron Microscopy
3.04Å resolution

Cryo-EM structure of the GI.4 Chiba VLP complexed with the CV-1A1 Fv-clasp

Released:
DOI: 10.2210/pdb8jg5/pdb
PDB entry 8jg5 coloured by chain, front view.
PDB entry 8jg5 coloured by chain, side view.
PDB entry 8jg5 coloured by chain, top view.
Source organisms:
Primary publication:
Structural analyses of the GI.4 norovirus by cryo-electron microscopy and X-ray crystallography revealing binding sites for human monoclonal antibodies.
Kimura-Someya T, Katsura K, Kato-Murayama M, Hosaka T, Uchikubo-Kamo T, Ihara K, Hanada K, Sato S, Murayama K, Kataoka M, Shirouzu M, Someya Y
OpenAccess logo J Virol e0019724 (2024)
PMID: 38593321
Related structures: EMD-36223

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero 420-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-274515 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Capsid protein Chains: A, B, G
Molecule details ›
Chains: A, B, G
Length: 542 amino acids
Theoretical weight: 58.11 KDa
Source organism: Chiba virus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9DU46 (Residues: 3-544; Coverage: 100%)
Gene name: ORF2
Sequence domains:
Serine/threonine-protein kinase 4 18kDa subunit Chains: C, E
Molecule details ›
Chains: C, E
Length: 178 amino acids
Theoretical weight: 19.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13043 (Residues: 431-480; Coverage: 10%)
Gene names: KRS2, MST1, STK4
Sequence domains: C terminal SARAH domain of Mst1
Serine/threonine-protein kinase 4 18kDa subunit Chains: D, F
Molecule details ›
Chains: D, F
Length: 169 amino acids
Theoretical weight: 18.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13043 (Residues: 340-349, 350-395, 396-408, 409-480; Coverage: 29%)
Gene names: KRS2, MST1, STK4
Sequence domains: C terminal SARAH domain of Mst1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.04Å
Relevant EMDB volumes: EMD-36223
Expression systems:
  • Spodoptera frugiperda
  • Escherichia coli

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