› 8jgv

Electron Microscopy
2.98Å resolution

Cryo-EM structure of mClC-3_I607T with ATP

Released:
DOI: 10.2210/pdb8jgv/pdb
PDB entry 8jgv coloured by chain, front view.
PDB entry 8jgv coloured by chain, side view.
PDB entry 8jgv coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural basis of adenine nucleotides regulation and neurodegenerative pathology in ClC-3 exchanger.
Wan Y, Guo S, Zhen W, Xu L, Chen X, Liu F, Shen Y, Liu S, Hu L, Wang X, Ye F, Wang Q, Wen H, Yang F
Nat Commun 15 6654 (2024)
PMID: 39107281
Related structures: EMD-36246

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-273849 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
H(+)/Cl(-) exchange transporter 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 818 amino acids
Theoretical weight: 90.95 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: P51791 (Residues: 1-818; Coverage: 100%)
Gene names: Clc3, Clcn3
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand ATP 2 x ATP
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.98Å
Relevant EMDB volumes: EMD-36246
Expression system: Homo sapiens

Quick links