› 8jh7

Electron Microscopy
3.2Å resolution

FZD6 in inactive state

Released:
DOI: 10.2210/pdb8jh7/pdb
PDB entry 8jh7 coloured by chain, front view.
PDB entry 8jh7 coloured by chain, side view.
PDB entry 8jh7 coloured by chain, top view.
Source organisms:
Primary publication:
A framework for Frizzled-G protein coupling and implications to the PCP signaling pathways.
Zhang Z, Lin X, Wei L, Wu Y, Xu L, Wu L, Wei X, Zhao S, Zhu X, Xu F
OpenAccess logo Cell Discov 10 3 (2024)
PMID: 38182578
Related structures: EMD-36258

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-238912 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
anti-BRIL Fab Heavy chain Chain: H
Molecule details ›
Chain: H
Length: 240 amino acids
Theoretical weight: 25.7 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
anti-Fab Nanobody Chain: K
Molecule details ›
Chain: K
Length: 127 amino acids
Theoretical weight: 14.08 KDa
Source organism: synthetic construct
Expression system: Escherichia coli
anti-BRIL Fab Light chain Chain: L
Molecule details ›
Chain: L
Length: 212 amino acids
Theoretical weight: 23.21 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
Frizzled-6; Soluble cytochrome b562 Chain: D
Molecule details ›
Chain: D
Length: 641 amino acids
Theoretical weight: 73.46 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O60353 (Residues: 18-396, 408-510; Coverage: 70%)
  • Canonical: P0ABE7 (Residues: 23-127; Coverage: 99%)
Gene names: FZD6, cybC
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.2Å
Relevant EMDB volumes: EMD-36258
Expression systems:
  • Trichoplusia ni
  • Escherichia coli
  • Spodoptera frugiperda

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