› 8jig

X-ray diffraction
2.4Å resolution

A Novel UHRF1-Targeted Compound

Released:
DOI: 10.2210/pdb8jig/pdb
PDB entry 8jig coloured by chain, front view.
PDB entry 8jig coloured by chain, side view.
PDB entry 8jig coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Chen Y, Jiang L

Function and Biology Details

Reaction catalysed: 
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-572620 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
E3 ubiquitin-protein ligase UHRF1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 212 amino acids
Theoretical weight: 23.77 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96T88 (Residues: 413-617; Coverage: 26%)
Gene names: ICBP90, NP95, RNF106, UHRF1
Sequence domains: SAD/SRA domain

Ligands and Environments

1 bound ligand:
Ligand 8JA 2 x 8JA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P31
Unit cell:
a: 65.875Å b: 65.875Å c: 95.634Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.208 0.208 0.244
Expression system: Escherichia coli

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