› 8jj2

Electron Microscopy
4.3Å resolution

Cryo-EM structure of GluN1-2A NMDAR in complex with human Fab2G7 in one fab conformation

Released:
DOI: 10.2210/pdb8jj2/pdb
PDB entry 8jj2 coloured by chain, front view.
PDB entry 8jj2 coloured by chain, side view.
PDB entry 8jj2 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Wang H, Zhu S
Related structures: EMD-36338

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-245550 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (5 distinct):
Glutamate receptor ionotropic, NMDA 2A Chains: A, C
Molecule details ›
Chains: A, C
Length: 841 amino acids
Theoretical weight: 94.14 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q12879 (Residues: 1-841; Coverage: 57%)
Gene names: GRIN2A, NMDAR2A
Sequence domains:
Glutamate receptor ionotropic, NMDA 1 Chains: B, D
Molecule details ›
Chains: B, D
Length: 847 amino acids
Theoretical weight: 95.24 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q05586 (Residues: 1-847; Coverage: 90%)
Gene names: GRIN1, NMDAR1
Sequence domains:
Fab2G7 Heavy Chain Chain: E
Molecule details ›
Chain: E
Length: 253 amino acids
Theoretical weight: 26.89 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Fab2G7 Light Chain Chain: F
Molecule details ›
Chain: F
Length: 234 amino acids
Theoretical weight: 25.76 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 8 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.3Å
Relevant EMDB volumes: EMD-36338
Expression system: Homo sapiens

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