› 8jj2

Electron Microscopy
4.3Å resolution

Cryo-EM structure of GluN1-2A NMDAR in complex with human Fab2G7 in one fab conformation

Released:
DOI: 10.2210/pdb8jj2/pdb
PDB entry 8jj2 coloured by chain, front view.
PDB entry 8jj2 coloured by chain, side view.
PDB entry 8jj2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for antibody-mediated NMDA receptor clustering and endocytosis in autoimmune encephalitis.
Wang H, Xie C, Deng B, Ding J, Li N, Kou Z, Jin M, He J, Wang Q, Wen H, Zhang J, Zhou Q, Chen S, Chen X, Yuan TF, Zhu S
Nat Struct Mol Biol (2024)
PMID: 39227720
Related structures: EMD-36338

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-274450 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (5 distinct):
Glutamate receptor ionotropic, NMDA 2A Chains: A, C
Molecule details ›
Chains: A, C
Length: 841 amino acids
Theoretical weight: 94.14 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q12879 (Residues: 1-841; Coverage: 57%)
Gene names: GRIN2A, NMDAR2A
Sequence domains:
Glutamate receptor ionotropic, NMDA 1 Chains: B, D
Molecule details ›
Chains: B, D
Length: 847 amino acids
Theoretical weight: 95.24 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q05586 (Residues: 1-847; Coverage: 90%)
Gene names: GRIN1, NMDAR1
Sequence domains:
Fab2G7 Heavy Chain Chain: E
Molecule details ›
Chain: E
Length: 253 amino acids
Theoretical weight: 26.89 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Fab2G7 Light Chain Chain: F
Molecule details ›
Chain: F
Length: 234 amino acids
Theoretical weight: 25.76 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 8 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.3Å
Relevant EMDB volumes: EMD-36338
Expression system: Homo sapiens

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