› 8jju

X-ray diffraction
1.46Å resolution

Crystal structure of QD-hNTAQ1 C28S

Released:
DOI: 10.2210/pdb8jju/pdb
PDB entry 8jju coloured by chain, front view.
PDB entry 8jju coloured by chain, side view.
PDB entry 8jju coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural study for substrate recognition of human N-terminal glutamine amidohydrolase 1 in the arginine N-degron pathway.
Kang JM, Park JS, Lee JS, Jang JY, Han BW
Protein Sci 33 e5067 (2024)
PMID: 38864716

Function and Biology Details

Reaction catalysed: 
N-terminal L-glutaminyl-[protein] + H(2)O = N-terminal L-glutamyl-[protein] + NH(3)
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188528 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein N-terminal glutamine amidohydrolase Chains: A, B
Molecule details ›
Chains: A, B
Length: 204 amino acids
Theoretical weight: 23.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96HA8 (Residues: 1-202; Coverage: 99%)
Gene names: C8orf32, NTAQ1, WDYHV1
Sequence domains: N-terminal glutamine amidase

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 5C (4A)
Spacegroup: P21
Unit cell:
a: 43.896Å b: 64.373Å c: 80.047Å
α: 90° β: 99.07° γ: 90°
R-values:
R R work R free
0.18 0.179 0.204
Expression system: Escherichia coli

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