› 8jl1

Electron Microscopy
2.8Å resolution

membrane proteins

Released:
DOI: 10.2210/pdb8jl1/pdb
PDB entry 8jl1 coloured by chain, front view.
PDB entry 8jl1 coloured by chain, side view.
PDB entry 8jl1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure and mechanism of lysosome transmembrane acetylation by HGSNAT.
Xu R, Ning Y, Ren F, Gu C, Zhu Z, Pan X, Pshezhetsky AV, Ge J, Yu J
Nat Struct Mol Biol 31 1502-1508 (2024)
PMID: 38769387
Related structures: EMD-36386

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-280577 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Heparan-alpha-glucosaminide N-acetyltransferase Chains: A, B
Molecule details ›
Chains: A, B
Length: 706 amino acids
Theoretical weight: 77.18 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
8 bound ligands:
Ligand ACO 2 x ACO
Ligand NAG 2 x NAG
Ligand D12 6 x D12
Ligand OCT 32 x OCT
Ligand C14 24 x C14
Ligand CLR 2 x CLR
Ligand D10 2 x D10
Ligand R16 2 x R16
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.8Å
Relevant EMDB volumes: EMD-36386
Expression system: Homo sapiens

Quick links

Citations

1 citations in other articles

Structure of the human heparan-α-glucosaminide N-acetyltransferase (HGSNAT).
Navratna et al. (2024)