Function and Biology

Cryo-EM structure of the human nucleosome with scFv

Source organism: Homo sapiens
Biochemical function: protein heterodimerization activity
Biological process: chromatin organization
Cellular component: chromosome

Sequence families

Pfam Protein families (Pfam)
PF00125
Domain description: Core histone H2A/H2B/H3/H4
Occurring in:
  1. Histone H3.1
  2. Histone H2A type 1-B/E
  3. Histone H2B type 1-J
The deposited structure of PDB entry 8jl9 contains 2 copies of Pfam domain PF00125 (Core histone H2A/H2B/H3/H4) in Histone H3.1. Showing 1 copy in chain A.
The deposited structure of PDB entry 8jl9 contains 2 copies of Pfam domain PF00125 (Core histone H2A/H2B/H3/H4) in Histone H2A type 1-B/E. Showing 1 copy in chain C.
The deposited structure of PDB entry 8jl9 contains 2 copies of Pfam domain PF00125 (Core histone H2A/H2B/H3/H4) in Histone H2B type 1-J. Showing 1 copy in chain D.

PF16211
Domain description: C-terminus of histone H2A
Occurring in:
  1. Histone H2A type 1-B/E
The deposited structure of PDB entry 8jl9 contains 2 copies of Pfam domain PF16211 (C-terminus of histone H2A) in Histone H2A type 1-B/E. Showing 1 copy in chain C.

PF15511
Domain description: Centromere kinetochore component CENP-T histone fold
Occurring in:
  1. Histone H4
The deposited structure of PDB entry 8jl9 contains 2 copies of Pfam domain PF15511 (Centromere kinetochore component CENP-T histone fold) in Histone H4. Showing 1 copy in chain B.