› 8jli

Electron Microscopy
3.38Å resolution

Cryo-EM structure of SV2A dimer in complex levetiracetam

Released:
DOI: 10.2210/pdb8jli/pdb
PDB entry 8jli coloured by chain, front view.
PDB entry 8jli coloured by chain, side view.
PDB entry 8jli coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for antiepileptic drugs and botulinum neurotoxin recognition of SV2A.
Yamagata A, Ito K, Suzuki T, Dohmae N, Terada T, Shirouzu M
OpenAccess logo Nat Commun 15 3027 (2024)
PMID: 38637505
Related structures: EMD-36398

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-243815 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Synaptic vesicle glycoprotein 2A Chains: A, B
Molecule details ›
Chains: A, B
Length: 750 amino acids
Theoretical weight: 83.77 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q7L0J3 (Residues: 2-742; Coverage: 100%)
Gene names: KIAA0736, PSEC0174, SV2A
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand UKX 2 x UKX
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.38Å
Relevant EMDB volumes: EMD-36398
Expression system: Spodoptera frugiperda

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